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These results highlight that even partial vaccination with a leaky vaccine can have unforeseen positive consequences in controlling the spread and symptoms of disease For example, the new vaccines can cause myocarditis (inflammation of the heart muscle) in a small fraction of young men, and one study reported seven severe cases of shingles for every million shots administered. Leaky vaccination of chickens infected with marek“s disease virus reduced symptoms and lowered mortality in the unvaccinated contact birds infected by them.
But what about human diseases As the pathogen passes between vaccinated hosts, it can gain virulence without killing them — with severe consequences for any. Most human vaccines in use today aren't leaky
They are very good at stopping disease transmission
But as researchers turn to diseases that are more difficult to protect against, such as malaria or hiv, they are setting their sights lower, aiming for vaccines that prevent severe disease but not infection. Our malaria models were some of the first that used a leaky vaccine mechanism. A leaky vaccine removes this pressure to become less virulent
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