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缝隙连接(Gap junction),又称通讯连接,是一种细胞间连接形式,分布于除血细胞和骨骼肌细胞外的多数组织细胞间,呈斑状的分散局部连接。 缝隙连接(间隙连接)是多种动物细胞类型之间的一种特殊细胞间连接。 [1][2][3] 它们将两个细胞的细胞质直接相连,使各种分子、离子和电脉冲直接穿过细胞间的调节通道。 细胞连接(cell junction)是指细胞间或者细胞与细胞外基质通过细胞表面的特化结构而连接在一起,形成功能性结构的过程。

间隙连接 (英語: Gap junction),或称 缝隙连接,是 细胞连接 的一种,神经细胞之间的间隙连接又称 电突触 (Electrical synapse),是一种特化的动物 细胞 间连接,广泛地存在于各种动物组织中。 缝隙连接是一种动态结构,有多种因素参与调节通道的开放和关闭,如细胞内pH、Ca2+浓度和 细胞膜 电位 等。 缝隙连接有多种功能,它与细胞的 代谢 和 分化,物质的运输和电兴奋的 传导 等有密切关系。 结构:相邻细胞膜形成约2-4个点状融合,蛋白颗粒(claudin & occludin)对接,形成2-4条嵴线,嵴线交错成网,环绕细胞,非融合处有极窄的细胞间隙(10-15nm)。

本文综述缝隙连接在细胞屏障中的作用及其与疾病发生发展的相关性。

细胞与细胞间的缝隙连接是细胞间通讯联系和物质转运的重要通道,几乎普遍存在于各种组织中,并具有节律性和整合性等特点。 生物体大多数组织相邻细胞膜上存在特殊的连接通道,以实现细胞间化学信号和电信号的通讯联系,从而完成群体细胞间的合作和协调,这种连接方式称为通讯连接。 细胞间隙连接(gap junction)是动物细胞间直接通讯的结构,由连接蛋白(connexin)组成的连接子对接形成,允许相邻细胞交换如Ca²⁺、cAMP等信号物质,实现电耦联和协同反应。

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